| | | |  | | | | | | | | | | | | | | | |  | | | | :: | | | :: | | | :: | | | :: | | | :: | | | :: | | | :: | | | :: | | | :: | | | :: | | | | | | | | | | | | | | | | | RNAi Software Sponsored Links - Rational siRNA Design Template
 - A downloadable Excel template in which you can paste a sequence and it will give multiple siRNA target sequences. It uses the algorithm from Reynolds A et al. (2004) Rational siRNA design for RNA interference. Nature Biotechnology 22:326-330 and uses the formulae for calculating molecular weights and Tm from Oligo Calculator. (Rate:
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) - siRNA DNA Designer - siRNA DNA Designer 1.5 automates the process of designing oligonucleotides for DNA-directed siRNA. The program provides tools for narrowing the number of candidate siRNA sequences and RNA Pol III and RNA Pol II promoter choices. The multi-layered optimization approach of siRNA DNA Designer 1.5 responds to the problem that the optimal siRNA target sequence can not be predicted, and the choice of RNA Pol III and Pol II promoters used exert cell, species, and tissue type effects on expression efficiencies. A complementary approach of computation, and laboratory testing is necessitated. DNA-directed siRNA offers many relative advantages to chemically synthesized siRNA. Free demo download. (Rate:
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